True friendship is a blessing and Gul-o-Gulzar is a story of two friends who are very close to each other. But unfortunately, Gul’s envious nature destroys their bond completely.

Saboor Aly as Gul is a manipulative and envious girl, who belongs to a poverty-stricken family and wants to get married to a rich guy.

Kinza Hashmi as Gulzar is a soft-hearted and simple girl, who faces humiliation due to her friend (Gul’s) affair with Adil.

Paras Mansoor as Jamal is a simple and self-made person who marries Gulzar despite all the allegations from Gul’s Parents. Jamal’s steadfast nature impresses Gulzar and she starts liking him.

Firdous Jamal as Master Iqbal is a School teacher and respected father of Gulzar. His upbringing saves the entire family from the wrath of Gul’s devious plans.

Omer Shahzad as Adil is flirtatious and a liar who likes Gulzar initially and gets into Gul’s deception easily and marries her.

Kunwar Nafees as Afaq is Gulzar’s elder brother who becomes the victim of his sister’s vicious friend Gul, as she steals all the jewelry a day before his wedding.