At least 14 people have been killed in a bombing outside a polio vaccination centre in the south-western Pakistani city of Quetta, officials say.
Many of the casualties are thought to have been police guarding the clinic.
Armed guards are routine for polio workers in Pakistan, who have been the target of many deadly attacks by Islamist militants in recent years.
Militants oppose polio vaccination, saying it is a Western conspiracy to sterilise Pakistani children.
Pakistan and Afghanistan are the only two countries where the disease is still endemic.
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