The Arizona Cardinals will wind up a disappointing season as they face NFC west division rival the San Francisco 49ers in an NFL pro football game on Sunday afternoon. Kick off time from San Francisco is scheduled for 4:25PM Eastern Time with national television coverage provided by FOX.

The betting odds from this NFL game opened up with the home team San Francisco 49ers favored by -16 points with an over under line of 38 ½ points. Early money from the bettors has landed on the home side as San Francisco is now favored by -17 points. The over under line has not moved off the opener of 38 ½ points.

In their first meeting it was San Francisco with the 24-3 road win at Arizona as a -7 point betting favorite. The total landed under 37 ½ points. The Cardinals offense just like it has been all season produced an anemic performance with just 265 yards for the game with seven yards running the ball. NFL Trend: San Francisco 49ers are 7-1 ATS in their past eight meetings with the Arizona Cardinals.

Arizona heads to San Francisco with a mark of 5-10 on the year. The team is 1-6 on the road. This is one of the nastier NFC divisional rivalries and just because the Cardinals are out doesn’t mean they will not come with a fight. They don’t like San Francisco. With like any other playoff eliminated team is the Cardinals get down by three scores or more don’t look for much of a comeback. Especially from the NFL’s worst offense that produced a mere 263 yards a game. They are at or near the bottom in passing, rushing and scoring. Defensively the team allows 195 yards passing good for third in the NFL. Arizona posts the 12th ranked defense in the league allowing 333 yards a game. Last week they fall to Chicago 28-13 as a +7 point underdog. Arizona produces just 248 yards all game long. Quarterback Brian Lindley completes 52% of his passes with 0 touchdowns and 7 interceptions.

The 49ers enter play with a mark of 10-4-1 on the year. With a win on Sunday they will win the NFC West division. They can also win the division with a Seahawks loss to the Rams. San Francisco can earn a first round bye in the playoffs with a win and Green Bay loss. A Packers loss is possible as they travel to Minnesota who needs a win to clinch a wildcard berth. San Francisco has their two game win streak snapped in a 42-13 road loss last week to the Seattle Seahawks as a +2 ½ point underdog on Sunday Night Football. The 49ers got crushed by the Seahawks run attack as they allow 176 yards on the ground. They give up four Seattle touchdowns in their four red zone attempts while the 49ers push across just one touchdown in four red zone tries. The 49ers own the second best defense in the NFL by allowing just 296 yards a game. They have been good this season in defending both the run and pass. Teams score just 17 points a game against San Francisco good for third in the NFL. Quarterback Colin Kaepernick has completed 63% of his throws with 8 touchdowns and 3 picks.