Duke Is the Huge Favorite to Win March Madness This Year According to ESPN, Vegas odds have br the Blue Devils at 21. The University of Kentucky in 2015 were the last team to be this favored. After an undefeated season, the Wildcats were upset by Wisconsin in the Final Four. Nearly 60 of them have Zion Williamson and Duke winning the title. Second favored is Duke's longtime rivals, the University of North Carolina. After Duke and UNC, Virginia and Gonzaga currently have the next best odds br of winning. Round 1 of the tournament br starts this Thursday.