The assessment of patient reported outcomes and health-related quality of life continue to be rapidly evolving areas of research and this new edition reflects the development within the field from an emerging subject to one that is an essential part of the assessment of clinical trials and other clinical studies.The analysis and interpretation quality-of-life relies on a variety of psychometric and statistical methods which are explained in this book in a non-technical way. The result is a practical guide that covers a wide range of methods and emphasizes the use of simple techniques using numerous examples. The material in this new third edition has been reorganized to reflect current teaching methods and the content has been widened to address continuing developments in item response theory, computer adaptive testing, analyses with missing data, Bayesian methods, systematic reviews and meta-analysis. Chapters have also been extended to cover in more detail qualitative methods, the impact of guidelines, the analysis of ordinal data and bootstrap methods.This book is aimed at everyone involved in quality-of-life research and is applicable to medical and non-medical, statistical and non-statistical readers. It is of particular relevance for clinical and biomedical researchers within both the pharmaceutical industry and clinical practice.