Any problem in-urine can be a sign of kidney problem. Protein in urine-can be a sign of kidney disease. Actually, there is a protein called albumin in the blood. Which help us to clean substances like urea and creatinine from the blood. Albumin proteins help us to remove the urea and creatinine present in the blood from the body, but albumin is not removed along with it. But when a protein called albumin starts coming out through-urine, it can be a sign of kidney disease. Albumin is a simple protein that comes out in th-urine due to decreased kidney function or kidney damage.