Raw Organic Blue Green Algaebr br br High Fructose Corn Syrup Fructose also does not help in the production of leptin, which is produced in fat cells of the body. Both insulin and leptin have an important role in regulating the appetite as they can act as suppressants. br br With an increased consumption of HFCS in the body, you only experience an increase in calorie consumption and in the process, tend to gain more weight as the stimulation of the production of insulin and leptin are both reduced.