DIABETIC NEPHROPATHY causes شرح بالعربىbr It is now the most common cause of end-stage renal failure in developed countries and accounts for between 20 and 50 of patients starting renal replacement therapy.br About 30 of patients with type 1 diabetes have developed diabetic nephropathy 20 years after diagnosis, but the risk after this time falls to less than1 per year, and from the outset the risk is not equal in all patients.br Some patients do not develop nephropathy, however, despite having long-standing, poorly controlled diabetes. br suggesting that they do not have genetic predisposition.