br br One in every 8 new mothers experience postpartum depression. The number is surging with a 7-fold increase over a 15 year period. The FDA has now approved the oral neuronsteroid drug zuranolone, branded by Sage TherapeuticsBiogen as Zurzuvae. This drug is a synthetic version of the naturally occurring allopregnanolone that stimulates the brain’s GABA-A receptors leading to a calming and antidepressant effect. Phase 3 clinical trials have demonstrated that this oral drug works to effectively ease depression within 3 days whereas conventional therapy requires injections and may take weeks to become effective. The downside: the drug passes into breast milk precluding breast-feeding until studies show that zuranolone is safe for newborns.