| IKENNA IKE | THE MOST SUCCESSFUL NFL TEAMS OF ALL TIME: SAN FRANCISCO 49ERS (PART 3) (@IKENNAIKE)br The San Francisco 49ers have left an indelible mark on the NFL landscape, boasting five Super Bowl victories and a regular-season win-loss percentage of .532. Pioneers of the West Coast offense, the 49ers revolutionized offensive strategies in the league.