Christina Applegate Doesn’t ‘Enjoy Living’ , Because of MS.br In August of 2021, Applegate announced that she'd been diagnosed with multiple sclerosis (MS).br On June 4, Applegate revealed on the br 'MeSsy' podcast that she's dealing with br a deep depression, 'Page Six' reports. .br I’m in a depression right now, which br I don’t think I’ve felt that for years, Christina Applegate, on the 'MeSsy' podcast.br Like a real, f----it-all depression where br it’s kind of scaring me, too, a little bit br because it feels really fatalistic. , Christina Applegate, on the 'MeSsy' podcast.br I’m trapped in, like, this darkness br right now that I haven’t felt [in], br like, I don’t even know how long, br probably 20-something years, Christina Applegate, on the 'MeSsy' podcast.br This is being really honest … br I don’t enjoy living. I don’t enjoy it. br I don’t enjoy things anymore, Christina Applegate, on the 'MeSsy' podcast.br 'MeSsy' co-host Jamie-Lynn Sigler, br who has been fighting MS for over 20 years, acknowledged Applegate's struggle. .br Once we get you to this place where br we’re accepting that this is how it’s br going to be, maybe forever…, Jamie-Lynn Sigler, on the 'MeSsy' podcast.br ... [coping with MS] is not a reason br enough for you to stop living because br I sit here across from you, and you still br make me laugh like nobody else can, Jamie-Lynn Sigler, on the 'MeSsy' podcast.br Applegate went on to say that she had been putting off seeing her therapist because she didn't want to open the "floodgates.".br I’m so afraid for those floodgates to br open and that I won’t be able to stop, Christina Applegate, on the 'MeSsy' podcast.