In his quest to reincarnate his bitten ladylove, 19th-century vampire-hunter Dr. Abraham Van Helsing (Rhett Giles) becomes an immortal. Decades later, when blood-drained bodies begin arriving at the hospital where Van Helsing works in contemporary Los Angeles, the good doctor recruits and trains a new batch of vampire hunters. With the help of the Rev. Cefalu (Anthony Turk), Van Helsing and his team struggle to find and destroy Sebastien (Andreas Beckett) -- the last of Dracula's line.