The "Are You Sure?" meme is a viral edit format based on a scene from the animated series Invincible, in which Omni-Man skeptically asks his son Mark, “Are you sure?” after Mark reveals he has powers. In March 2025, TikTok users began remixing the clip into chaotic YTP-style edits, often layering it with distorted visuals, absurd scenarios, or dramatic moments from the show and beyond. The meme quickly became a new staple of brainrot meme culture.