Eddie Guerrero vs. Rey Mysterio at WrestleMania 21 is remembered as a fast-paced, emotionally charged match that combined elite in-ring chemistry with layered storytelling between two lifelong rivals.br br The bout leaned heavily on speed, technique, and familiarity. Rey used constant movement, quick strikes, and aerial offense to stay one step ahead, while Eddie countered with crisp technical wrestling, timing, and clever manipulation of momentum. Their long history was evident in how smoothly they anticipated each other’s counters and transitions.